… that high glucose induced mesangial cell EGFR transactivation through Src kinase stimulation.
… In summary, Src activation occurs in mesangial cells exposed to high glucose and in the …

… that EGFR–PI3K–Akt signalling mediates high glucose-induced … is the pathogenic hallmark
of diabetic renal disease, we studied … whether EGFR transactivation might play a role in high …

… , diabetic nephropathy, hypertensive nephropathy, and glomerulonephritis … transactivation
of EGFR by high glucose leads to collagen synthesis in mesangial cells, and EGFR inhibition …

… This study highlights the importance of Src in diabetic nephropathy. Mesangial cell
proliferation is an important pathological phenomenon in DN (81). High glucose induced the …

… isozymes implicated in diabetic kidney disease as evidenced by … revealed that inhibition of
Src with chemical inhibitors blocked … of a Src inhibitor to STZ-injected diabetic mice inhibited …

… is a hallmark of diabetic nephropathy. We showed that … inhibitors of the most common
potential mediators of EGFR … of ADAM17 in glucose-induced EGFR transactivation, we assessed …

… in diabetic nephropathy and elucidate its possible mechanism. … Inhibition of Src kinase
blocks high glucose-induced EGFR transactivation and collagen synthesis in mesangial cells …

… Diabetic nephropathy (DN) is one of the most serious microvascular … -Src is sensitive to
oxidative stress, and inhibition of c-Src activity blocks high glucose-induced EGFR transactivation …

… diabetic mice compared with the EGFR podKO diabetic mice (… inhibition of c-Src kinase
prevented progression of diabetic … high-glucose–induced TGFβ-Smad2/3 signaling activation and …

… showed that ADAM17 mediates high glucose-induced matrix production by kidney … inhibition
thus provides a potential novel therapeutic strategy for the treatment of diabetic nephropathy…